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    Best in class: a good principle for antibiotic usage to limit resistance development?


    Amyes, Sebastian G.B. and Walsh, Fiona and Bradley, John S. (2007) Best in class: a good principle for antibiotic usage to limit resistance development? Journal of Antimicrobial Chemotherapy, 59. pp. 825-826. ISSN 0305-7453

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    Abstract

    The causes of antibiotic resistance are often complex and it is difficult to identify strategies to prevent or delay its emergence. One strategy has been to use less active members of a drug class, so that when resistance develops the more active members will still prevail. This stratagem may often fail because this resistance may form the basis of resistance to the whole class. Often, less active drugs are the first to be discovered and more active versions follow, so we have had no choice; however, increasingly less active drugs are available to deal with specific infections and this may have a detrimental effect on the class as a whole.

    Item Type: Article
    Keywords: antimicrobial management; therapy; carbapenems;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 12672
    Identification Number: https://doi.org/10.1093/jac/dkm059
    Depositing User: Fiona Walsh
    Date Deposited: 31 Mar 2020 12:52
    Journal or Publication Title: Journal of Antimicrobial Chemotherapy
    Publisher: Oxford University Press
    Refereed: Yes
    URI:

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