de Vries, Paul S. and Chasman, Daniel I. and Sabater-Lleal, Maria and Chen, Ming-Huei and Huffman, Jennifer E. and Steri, Maristella and Tang, Weihong and Teumer, Alexander and Marioni, Riccardo E. and Grossmann, Vera and Hottenga, Jouke J. and Trompet, Stella and Müller-Nurasyid, Martina and Zhao, Jing Hua and Brody, Jennifer A. and Kleber, Marcus E. and Guo, Xiuqing and Wang, Jie Jin and Auer, Paul L. and Attia, John R. and Yanek, Lisa R. and Ahluwalia, Tarunveer S. and Lahti, Jari and Venturini, Cristina and Tanaka, Toshiko and Bielak, Lawrence F. and Joshi, Peter K. and Rocanin-Arjo, Ares and Kolcic, Ivana and Navarro, Pau and Rose, Lynda M. and Oldmeadow, Christopher and Riess, Helene and Mazur, Johanna and Basu, Saonli and Goel, Anuj and Yang, Qiong and Ghanbari, Mohsen and Willemsen, Gonneke and Rumley, Ann and Fiorillo, Edoardo and de Craen, Anton J. M. and Grotevendt, Anne and Scott, Robert and Taylor, Kent D. and Delgado, Graciela E. and Yao, Jie and Kifley, Annette and Kooperberg, Charles and Qayyum, Rehan and Lopez, Lorna M. and Berentzen, Tina L. and Räikkönen, Katri and Mangino, Massimo and Bandinelli, Stefania and Peyser, Patricia A. and Wild, Sarah and Trégouët, David-Alexandre and Wright, Alan F. and Marten, Jonathan and Zemunik, Tatijana and Morrison, Alanna C. and Sennblad, Bengt and Tofler, Geoffrey and de Maat, Moniek P. M. and de Geus, Eco J. C. and Lowe, Gordon D. and Zoledziewska, Magdalena and Sattar, Naveed and Binder, Harald and Völker, Uwe and Waldenberger, Melanie and Khaw, Kay-Tee and Mcknight, Barbara and Huang, Jie and Jenny, Nancy S. and Holliday, Elizabeth G. and Qi, Lihong and Mcevoy, Mark G. and Becker, Diane M. and Starr, John M. and Sarin, Antti-Pekka and Hysi, Pirro G. and Hernandez, Dena G. and Jhun, Min A. and Campbell, Harry and Hamsten, Anders and Rivadeneira, Fernando and Mcardle, Wendy L. and Slagboom, P. Eline and Zeller, Tanja and Koenig, Wolfgang and Psaty, Bruce M. and Haritunians, Talin and Liu, Jingmin and Palotie, Aarno and Uitterlinden, André G. and Stott, David J. and Hofman, Albert and Franco, Oscar H. and Polasek, Ozren and Rudan, Igor and Morange, Pierre-Emmanuel and Wilson, James F. and Kardia, Sharon L. R. and Ferrucci, Luigi and Spector, Tim D. and Eriksson, Johan G. and Hansen, Torben and Deary, Ian J. and Becker, Lewis C. and Scott, Rodney J. and Mitchell, Paul and März, Winfried and Wareham, Nick J. and Peters, Annette and Greinacher, Andreas and Wild, Philipp S. and Jukema, J. Wouter and Boomsma, Dorret I. and Hayward, Caroline and Cucca, Francesco and Tracy, Russell and Watkins, Hugh and Reiner, Alex P. and Folsom, Aaron R. and Ridker, Paul M. and O'Donnell, Christopher J. and Smith, Nicholas L. and Strachan, David P. and Dehghan, Abbas (2015) A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. Human Molecular Genetics, 25 (2). pp. 358-370. ISSN 0964-6906

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Abstract

Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ∼120 000 participants of European ancestry (95 806 participants with data on the X-chromosome). Approximately 10.7 million single-nucleotide polymorphisms and 1.2 million indels were examined. We identified 41 genome-wide significant fibrinogen loci; of which, 18 were newly identified. There were no genome-wide significant signals on the X-chromosome. The lead variants of five significant loci were indels. We further identified six additional independent signals, including three rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.

Item Type:	Article
Keywords:	Ameta-analysis; 120 246 individuals; identifies; 18 new loci; fibrinogen concentration;
Academic Unit:	Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	17197
Identification Number:	https://doi.org/10.1093/hmg/ddv454
Depositing User:	Lorna Lopez
Date Deposited:	17 May 2023 10:16
Journal or Publication Title:	Human Molecular Genetics
Publisher:	Oxford University Press
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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