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    Chaperoning prions: the cellular machinery for propagating an infectious protein?


    Jones, Gary W. and Tuite, M.F. (2005) Chaperoning prions: the cellular machinery for propagating an infectious protein? BioEssays, 27. pp. 823-832.

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    Abstract

    Newly made polypeptide chains not only require the help of molecular chaperones to rapidly reach their final three-dimensional forms, but also to unfold and then correctly refold them back to their biologically active form should they misfold. Most prions are an unusual class of protein that can exist in one of two stable conformations, one of which leads to formation of an infectious alternatively folded form. Studies in Baker’s yeast (Saccharomyces cerevisiae) have revealed that prions can exploit the molecular chaperone machinery in the cell in order to ensure stable propagation of the infectious, aggregation-prone form. The disaggregation of yeast prion aggregates by molecular chaperones generates forms of the prion protein that can seed the protein polymerisation that underlies the prion propagation cycle. In this article we review what we have learnt about the role of molecular chaperones in yeast prion propagation, describe a model to that can explain the role of various classes of molecular chaperones and their co-chaperones, and speculate on the possible involvement of chaperones in the propagation of mammalian prions.

    Item Type: Article
    Keywords: Chaperoning prions; infectious protein;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 530
    Depositing User: Dr. Gary Jones
    Date Deposited: 18 May 2007
    Journal or Publication Title: BioEssays
    Publisher: Wiley
    Refereed: Yes
    URI:
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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