Burnell, Ann, Houthoofd, Koen, O'Hanlon, Karen and Vanfleteren, Jacques R. (2005) Alternate metabolism during the dauer stage of the nematode Caenorhabditis elegans. Experimental Gerontology, 40. pp. 850-856.
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Abstract
When environmental conditions are unsuitable to support nematode reproduction, Caenorhabditis elegans arrests development before the onset of sexual maturity and specialised �dauer� larvae, adapted for dispersal, and extended diapause are formed. Dauer larvae do not feed and their metabolism is dependent on internal food reserves. Adult worms which express defects in the insulin/insulin-like growth factor receptor DAF-2 also display enhanced longevity. Whole genome mRNA expression profiling has demonstrated that C. elegans dauer larvae and daf-2 adults have similar transcription profiles for a cohort of longevity genes. Important components of this enhanced longevity system are the a-crystallin family of small heat shock proteins, anti-ROS defence systems, increased activity of cellular detoxification processes and possibly also increased chromatin stability and decreased protein turnover. Anaerobic fermentation pathways are upregulated in dauer larvae, while long-lived daf-2 adults appear to have normal oxidative metabolism. Anabolic pathways are down regulated in dauer larvae (and possibly in daf-2 adults as well), and energy consumption appears to be diverted to enhanced cellular maintenance and detoxification processes in both systems.
Item Type: | Article |
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Keywords: | Dauer; Gene expression profiling; daf-2; Metabolism; Malate dismutation; ROS; a-crystallin; Detoxification; Longevity |
Academic Unit: | Faculty of Science and Engineering > Biology |
Item ID: | 515 |
Depositing User: | Prof. Ann Burnell |
Date Deposited: | 23 Sep 2008 |
Journal or Publication Title: | Experimental Gerontology |
Publisher: | Elsevier |
Refereed: | Yes |
Related URLs: | |
URI: | https://mural.maynoothuniversity.ie/id/eprint/515 |
Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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