Article

Tunstead, Courteney, Volkova, Evelina, Dunbar, Hazel, Hawthorne, Ian J., Bell, Alison, Crowe, Louise, Masterson, Joanne C., Dos Santos, Claudia C., McNicholas, Bairbre, Laffey, John G. and English, Karen (2024) The ARDS microenvironment enhances MSC-induced repair via VEGF in experimental acute lung inflammation. Molecular Therapy, 32 (10). pp. 3422-3432. ISSN 1525-0016

Dunbar, Hazel, Hawthorne, Ian J. and English, Karen (2024) Carbon monoxide licensing of MSCs enhances their efficacy through autophagy-mediated miRNA mechanisms. Molecular Therapy. ISSN 1525-0016

Dunbar, Hazel, Hawthorne, Ian James and English, Karen (2024) MAC attack: MSCs and macrophages join forces against chronic lung infection. Thorax. ISSN 0040-6376

Dunbar, Hazel, Hawthorne, Ian James and English, Karen (2024) MAC attack: MSCs and macrophages join forces against chronic lung infection. Thorax. ISSN 0040-6376

dos Santos, Claudia C., Lopes-Pacheco, Miquéias, English, Karen, Rolandsson Enes, Sara, Krasnodembskaya, Anna and Rocco, Patricia R. M. (2024) The MSC-EV-microRNAome: A Perspective on Therapeutic Mechanisms of Action in Sepsis and ARDS. Cells, 13 (2). p. 122. ISSN 2073-4409

Dunbar, Hazel, Hawthorne, Ian J., Tunstead, Courteney, McNamee, Eóin N., Weiss, Daniel J., Armstrong, Michelle E., Donnelly, Seamas C. and English, Karen (2024) Mesenchymal stromal cells dampen trained immunity in house dust mite-primed macrophages expressing human macrophage migration inhibitory factor polymorphism. Cytotherapy, 26 (10). pp. 1245-1251. ISSN 1465-3249

Dunbar, Hazel, Hawthorne, Ian J., McNamee, Eóin N., Armstrong, Michelle E., Donnelly, Seamas C. and English, Karen (2024) The human MIF polymorphism CATT7 enhances pro‐inflammatory macrophage polarization in a clinically relevant model of allergic airway inflammation. The FASEB Journal, 38 (6). ISSN 0892-6638

English, Karen (2023) Apoptotic MSCs, COX2/PGE2 and clinical efficacy in Crohn fistula. Molecular Therapy, 31 (12). ISSN 15250016

Dunbar, Hazel, Hawthorne, Ian J., Tunstead, Courteney, Armstrong, Michelle E., Donnelly, Seamas C. and English, Karen (2023) Blockade of MIF biological activity ameliorates house dust mite‐induced allergic airway inflammation in humanized MIF mice. The FASEB Journal, 37 (8). ISSN 0892-6638

Hawthorne, Ian J., Dunbar, Hazel, Tunstead, Courteney, Schorpp, Tamara, Weiss, Daniel J., Enes, Sara Rolandsson, dos Santos, Claudia C., Armstrong, Michelle E., Donnelly, Seamas C. and English, Karen (2023) Human macrophage migration inhibitory factor potentiates mesenchymal stromal cell efficacy in a clinically relevant model of allergic asthma. Molecular Therapy. pp. 1-44. ISSN 1525-0016

Gallagher, Catriona, Mahon, Julie Mac, O’Neill, Chloe, Cassidy, Féaron C., Dunbar, Hazel, De Barra, Conor, Cadden, Caoimhe, Pisarska, Marta M., Wood, Nicole, Masterson, Joanne C., McNamee, Eoin N., English, Karen, O’Shea, Donal, Tobin, Anne Marie and Hogan, Andrew E. (2023) Mucosal associated invariant T cells are altered in patients with Hidradenitis Suppurativa and contribute to the inflammatory milieu. Journal of Investigative Dermatology, 143 (6). pp. 1094-1097. ISSN 0022-202X

Healy, Marc, Aldridge, Allison, Glasgow, Arlene.M.A., Mahon, Bernard P., English, Karen and O'Neill, Sandra M. (2022) Helminth antigens modulate human PBMCs, attenuating disease progression in a humanised mouse model of graft versus host disease. Experimental Parasitology, 235 (108231). pp. 1-10. ISSN 0014-4894

Corbett, Jennifer M., Hawthorne, Ian, Dunbar, Hazel, Coulter, Ivan, Chonghaile, Mairead Ni, Flynn, Catherine M. and English, Karen (2021) Cyclosporine A and IFNγ licencing enhances human mesenchymal stromal cell potency in a humanised mouse model of acute graft versus host disease. Stem Cell Research & Therapy, 12 (238). pp. 1-10. ISSN 1757-6512

Corbett, Jennifer M., Hawthorne, Ian, Coulter, Ivan S. and English, Karen (2021) Drug delivery formulation impacts cyclosporine efficacy in a humanised mouse model of acute graft versus host disease. Transplant Immunology, 65. p. 101373. ISSN 0966-3274

Rolandsson Enes, Sara, Hampton, Thomas H., Barua, Jayita, McKenna, David H., dos Santos, Claudia C., Amiel, Eyal, Ashare, Alix, Liu, Kathleen D., Krasnodembskaya, Anna D., English, Karen, Stanton, Bruce A., Rocco, Patricia R.M., Matthay, Michael A. and Weiss, Daniel J. (2021) Healthy versus inflamed lung environments differentially affect mesenchymal stromal cells. European Respiratory Journal, 58 (200414). pp. 1-14. ISSN 0903-1936

Carty, Fiona, Dunbar, Hazel, Hawthorne, Ian J., Ting, Anthony E., Stubblefield, Samantha R., Van't Hof, Wouter and English, Karen (2021) IFN-γ and PPARδ Influence the Efficacy and Retention of Multipotent Adult Progenitor Cells in Graft vs Host Disease. Stem Cells Translational Medicine, 10 (11). pp. 1561-1574. ISSN 2157-6564

Rolandsson Enes, Sara, Krasnodembskaya, Anna D., English, Karen, Dos Santos, Claudia C. and Weiss, Daniel J. (2021) Research Progress on Strategies that can Enhance the Therapeutic Benefits of Mesenchymal Stromal Cells in Respiratory Diseases With a Specific Focus on Acute Respiratory Distress Syndrome and Other Inflammatory Lung Diseases. Frontiers in Pharmacology, 12. pp. 1-8. ISSN 1663-9812

Abreu, Soraia C., Hampton, Thomas H., Hoffman, Evan, Dearborn, Jacob, Ashare, Alix, Singh Sidhu, Karatatiwant, Matthews, Dwight E., McKenna, David H., Amiel, Eyal, Barua, Jayita, Krasnodembskaya, Anna, English, Karen, Mahon, Bernard P., Dos Santos, Claudia, Cruz, Fernanda F., Chambers, Daniel C., Liu, Kathleen D., Matthay, Michael A., Cramer, Robert A., Stanton, Bruce A., Rocco, Patricia R. M., Wargo, Matthew J., Weiss, Daniel J. and Rolandsson Enes, Sara (2020) Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells. American Journal of Physiology-Lung Cellular and Molecular Physiology, 319 (6). L908-L925. ISSN 1040-0605

Weiss, Daniel J., English, Karen, Krasnodembskaya, Anna, Isaza-Correa, Johana M., Hawthorne, Ian J. and Mahon, Bernard P. (2019) The Necrobiology of Mesenchymal Stromal Cells Affects Therapeutic Efficacy. Frontiers in Immunology, 10 (1228). ISSN 1664-3224

Carty, Fiona, Corbett, Jennifer, Cunha, João Paulo M. C. M., Reading, James, Tree, Timothy, Ting, Anthony E., Stubblefield, Samatha R. and English, Karen (2018) Multipotent Adult Progenitor Cells Suppress T Cell Activation in In Vivo Models of Homeostatic Proliferation in a Prostaglandin E2-Dependent Manner. Frontiers in Immunology, 6 (645). ISSN 1664-3224

Carty, Fiona, Mahon, Bernard P. and English, Karen (2017) The influence of macrophages on mesenchymal stromal cell therapy: passive or aggressive agents? Clinical and Experimental Immunology, 188. pp. 1-11. ISSN 1365-2249

Cahill, Emer, Kennelly, Helen, Carty, Fiona, Mahon, Bernard P. and English, Karen (2016) Hepatocyte Growth Factor Is Required for Mesenchymal Stromal Cell Protection Against Bleomycin-Induced Pulmonary Fibrosis. Stem Cells Translational Medicine, 5. pp. 1307-1318. ISSN 2157-6564

Kennelly, Helen, Mahon, Bernard P. and English, Karen (2016) Human mesenchymal stromal cells exert HGF dependent cytoprotective effects in a human relevant pre-clinical model of COPD. Scientific Reports, 6 (38207). ISSN 2045-2322

McClean, Siobhan, Healy, Mark E., Collins, Cassandra, Carberry, Stephen, O'Shaughnessy, Like, Dennehy, Ruth, Adams, Aine, Kennelly, Helen, Corbett, Jennifer, Carty, Fiona, Cahill, Laura A., Callaghan, Maire, English, Karen, Mahon, Bernard P., Doyle, Sean and Shinoy, Minu (2016) Linocin and OmpW Are Involved in Attachment of the Cystic Fibrosis-Associated Pathogen Burkholderia cepacia Complex to Lung Epithelial Cells and Protect Mice against Infection. Infection and Immunity, 84 (5). pp. 1424-1437. ISSN 0019-9567

Cahill, Emer, Tobin, Laura M., Carthy, Fiona, Mahon, Bernard P. and English, Karen (2015) Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells. Stem Cell Research and Therapy, 6 (19). ISSN 1757-6512

Healy, Marc E., Bergin, Ronan, Mahon, Bernard P. and English, Karen (2015) Mesenchymal Stromal Cells Protect Against Caspase 3-Mediated Apoptosis of CD19+ Peripheral B Cells Through Contact-Dependent Upregulation of VEGF. Stem Cells and Development, 24. pp. 2391-2402. ISSN 1547-3287

Reading, James, Vaes, Bart, Hull, Caroline, Sabbah, Shereen, Hayday, Thomas, Wang, Nancy S., DiPiero, Anthony, Lehman, Nocolas A., Taggart, Jen M., Carty, Fiona, English, Karen, Pinxteren, Jef, Deans, Robert, Ting, Anthony E. and Tree, Timothy (2015) Suppression of IL-7-dependent Effector T-cell Expansion by Multipotent Adult Progenitor Cells and PGE2. Molecular Therapy, 23 (11). pp. 1783-1793. ISSN 1525-0016

English, Karen, Mahon, Bernard P. and Wood, Kathryn J. (2014) Mesenchymal Stromal Cells; Role in Tissue Repair, Drug Discovery and Immune Modulation. Current Drug Delivery, 11 (5). pp. 561-571. ISSN 1567-2018

Maffioletti, Sara Martina, Noviello, Maddalena, English, Karen and Tedesco, Francesco Saverio (2014) Stem Cell Transplantation for Muscular Dystrophy: The Challenge of Immune Response. Boomed Research International (964010). ISSN 2314-6141

Griffin, Matthew D., Elliman, Stephen J, Cahill, Emer and English, Karen (2013) Concise Review: Adult Mesenchymal Stromal Cell Therapy for Inflammatory Diseases: How Well Are We Joining the Dots? Stem Cells, 31. pp. 2033-2041. ISSN 1549-4918

Li, Ou and English, Karen (2013) Human iPSC-derived mesoangioblasts, like their tissue-derived counterparts, suppress T cell proliferation through IDO- and PGE-2-dependent pathways. F1000 Research, 2 (24).

Tobin, Laura M., Healy, M.E., English, Karen and Mahon, Bernard P. (2013) Human mesenchymal stem cells suppress donor CD4+ T cell proliferation and reduce pathology in a humanized mouse model of acute graft-versus-host disease. Clinical and Experimental Immunology, 172. pp. 333-348. ISSN 1365-2249

Noone, Cariosa M., Kihm, Anthony, English, Karen and O'Dea, Shirley (2013) IFN-γ Stimulated Human Umbilical-Tissue-Derived Cells Potently Suppress NK Activation and Resist NK-Mediated Cytotoxicity In Vitro. Stem Cells and Development, 22. pp. 3003-3014. ISSN 1557-8534

English, Karen (2013) Mechanisms of mesenchymal stromal cell immunomodulation. Immunology and Cell Biology, 91. pp. 19-26. ISSN 1440-1711

English, Karen and Wood, Kathryn J. (2013) Mesenchymal Stromal Cells in Transplantation Rejection and Tolerance. Cold Spring Harbor perspectives in medicine, 3. ISSN 2157-1422

English, Karen, Tonlorenzi, Rossana, Cossu, Giulio and Wood, Kathryn J (2013) Mesoangioblasts Suppress T Cell Proliferation Through IDO and PGE-2-Dependent Pathways. Stem Cells and Development, 22 (3). pp. 512-523. ISSN 1547-3287

English, Karen and Mahon, Bernard P. (2011) Allogeneic Mesenchymal Stem Cells: Agents of Immune Modulation. Journal of Cellular Biochemistry, 112. pp. 1963-1968. ISSN 1097-4644

English, Karen (2011) Intervertebral Disc Repair: Mesenchymal Stem Cells to the Rescue? Transplantation, 92 (7). pp. 733-734. ISSN 0041-1337

Duffy, Michelle M., Pindjakova, Jana, Hanley, Shirley A., McCarthy, Cathal, Weidhofer, Gudrun A., Sweeney, Eva M., English, Karen, Shaw, Georgina, Murphy, J. Mary, Barry, Frank P., Mahon, Bernard P., Belton, Orina, Ceredig, Rhodri and Griffin, Matthew D. (2011) Mesenchymal stem cell inhibition of T-helper 17 cell- differentiation is triggered by cell–cell contact and mediated by prostaglandin E2 via the EP4 receptor. European Journal of Immunology, 41 (10). pp. 2840-2851. ISSN 1521-4141

Kavanagh, H,, Noone, C., Cahill, Emer, English, Karen, Locht, C. and Mahon, Bernard P. (2010) Attenuated Bordetella pertussis vaccine strain BPZE1 modulates allergen-induced immunity and prevents allergic pulmonary pathology in a murine model. Clinical & Experimental Allergy, 40 (6). pp. 933-941. ISSN 1365-2222

English, Karen, French, Anna and Wood, Kathryn J. (2010) Mesenchymal Stromal Cells: Facilitators of Successful Transplantation? Cell Stem Cell, 7. pp. 431-442. ISSN 1875-9777

English, Karen, Ryan, J.M., Tobin, L., Murphy, M.J., Barry, Frank P. and Mahon, Bernard P. (2009) Cell contact, prostaglandin E2 and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25High forkhead box P3+ regulatory T cells. Clinical and Experimental Immunology, 156. pp. 149-160.

Skerry, Ciaran M., Cassidy, Joseph P. and English, Karen (2009) A Live Attenuated Bordetella pertussis Candidate Vaccine Does Not Cause Disseminating Infection in Gamma Interferon Receptor Knockout Mice. Clinical and Vaccine immunology, 16 (9). pp. 1344-1351. ISSN 1556-679X

Field-Corbett, Ciara, English, Karen and O'Dea, Shirley (2009) Regulation of Surfactant Protein B Gene Expression in Bone Marrow-Derived Cells. Stem Cells, 27. pp. 662-669.

English, Karen, Barry, Frank P. and Mahon, Bernard P. (2008) Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation. Immunology Letters, 115. pp. 50-58.

English, Karen, Barry, Frank P., Field-Corbett, Ciara and Mahon, Bernard P. (2007) IFN-y and TNF-x differentially regulate immunomodulation by murine mesenchymal stem cells. Immunology Letters, 110. pp. 91-100. ISSN 1879-0542

English, Karen, Brady, Claire, Corcoran, Paul, Cassidy, Joseph P. and Mahon, Bernard P. (2006) Inflammation of the respiratory tract is associated with CCL28 and CCR10 expression in a murine model of allergic asthma. Immunology Letters, 103 (2). pp. 92-100. ISSN 0165-2478

English, Karen, Brady, Claire, Corcoran, Paul, Cassidy, Joseph P. and Mahon, Bernard P. (2006) Inflammation of the respiratory tract is associated with CCL28 andCCR10 expression in a murine model of allergic asthma. Immunology Letters, 103. pp. 92-100. ISSN 0165-2478

Harvey, Deirdre, Smith, Roisin, English, Karen, Mahon, Bernard P. and Commins, Sean (2006) Interleukin-10 (IL-10) but not Lipopolysaccharide (LPS) produces increased motor activity and abnormal exploratory patterns while impairing spatial learning in Balb/c mice. Physiology & Behavior, 87. pp. 842-847. ISSN 0031-9384/

Commins, Sean, Harvey, Deirdre, Smith, Roisin, English, Karen and Mahon, Bernard P. (2006) Interleukin-10 (IL-10) but not Lipopolysaccharide (LPS) produces increased motor activity and abnormal exploratory patterns while impairing spatial learning in Balb/c mice. Physiology and Behaviour, 87. pp. 842-847.

Barry, Frank P., Murphy, J. Mary, English, Karen and Mahon, Bernard P. (2005) Comprehensive Review: Immunogenicity of Adult Mesenchymal Stem Cells: Lessons from the Fetal Allograft. Stem Cells and Development, 14 (3). pp. 252-265. ISSN 1547-3287