Article

Ryan, Eimear K., Clutter, Christy, De Barra, Conor, Jenkins, Benjamin J., O’Shaughnessy, Simon, Ryan, Odhrán K., McKenna, Chloe, Heneghan, Helen M., Walsh, Fiona, Finlay, David K., Sinclair, Linda V., Jones, Nicholas, Leung, Daniel T., O’Shea, Donal and Hogan, Andrew E. (2024) Iron Is Critical for Mucosal-Associated Invariant T Cell Metabolism and Effector Functions. The Journal of Immunology. ISSN 0022-1767

Ryan, Eimear K., Clutter, Christy, De Barra, Conor, Jenkins, Benjamin J., O’Shaughnessy, Simon, Ryan, Odhrán K., McKenna, Chloe, Heneghan, Helen M., Walsh, Fiona, Finlay, David K., Sinclair, Linda V., Jones, Nicholas, Leung, Daniel T., O’Shea, Donal and Hogan, Andrew E. (2024) Iron Is Critical for Mucosal-Associated Invariant T Cell Metabolism and Effector Functions. The Journal of Immunology, 212 (11). pp. 1706-1713. ISSN 0022-1767

Cassidy, Féaron C., Kedia-Mehta, Nidhi, Bergin, Ronan, Woodcock, Andrea, Berisha, Ardena, Bradley, Ben, Booth, Eva, Jenkins, Benjamin J., Ryan, Odhrán K., Jones, Nicholas, Sinclair, Linda V., O’Shea, Donal and Hogan, Andrew E. (2023) Glycogen-fuelled metabolism supports rapid mucosal-associated invariant T cell responses. Proceedings of the National Academy of Sciences, 120 (25). ISSN 1091-6490

Gallagher, Catriona, Mahon, Julie Mac, O’Neill, Chloe, Cassidy, Féaron C., Dunbar, Hazel, De Barra, Conor, Cadden, Caoimhe, Pisarska, Marta M., Wood, Nicole, Masterson, Joanne C., McNamee, Eoin N., English, Karen, O’Shea, Donal, Tobin, Anne Marie and Hogan, Andrew E. (2023) Mucosal associated invariant T cells are altered in patients with Hidradenitis Suppurativa and contribute to the inflammatory milieu. Journal of Investigative Dermatology, 143 (6). pp. 1094-1097. ISSN 0022-202X

Cooper, Andrew J. R., Clegg, Jonah, Cassidy, Féaron C., Hogan, Andrew E. and McLoughlin, Rachel M. (2022) Human MAIT Cells Respond to Staphylococcus aureus with Enhanced Anti-Bacterial Activity. Microorganisms, 10 (148). pp. 1-19. ISSN 2076-2607

Wrigley Kelly, Neil E., Kenny, Grace, Cassidy, Féaron C., Garcia‐Leon, Alejandro A., De Barra, Conor, Mallon, Patrick W. G., Hogan, Andrew E. and O'Shea, Donal (2022) Individuals with obesity who survive SARS‐CoV‐2 infection have preserved antigen‐specific T cell frequencies. Obesity, 30 (10). pp. 1927-1931. ISSN 1930-7381

Schwartz, Christian, Schmidt, Viviane, Deinzer, Andrea, Hawerkamp, Heike C., Hams, Emily, Bayerlein, Jasmin, Röger, Ole, Bailer, Moritz, Krautz, Christian, El Gendy, Amr, Elshafei, Moustafa, Heneghan, Helen M., Hogan, Andrew E., O’Shea, Donal and Fallon, Padraic G. (2022) Innate PD-L1 limits T cell–mediated adipose tissue inflammation and ameliorates diet-induced obesity. Science Translational Medicine, 14 (635). ISSN 1946-6234

Dyck, Lydia, Prendeville, Hannah, Raverdeau, Mathilde, Wilk, Mieszko M., Loftus, Roisin M., Douglas, Aaron, McCormack, Janet, Moran, Bruce, Wilkinson, Michael, Mills, Evanna L., Doughty, Michael, Fabre, Aurelie, Heneghan, Helen, LeRoux, Carel, Hogan, Andrew E., Chouchani, Edward T., O’Shea, Donal, Brennan, Donal and Lynch, Lydia (2022) Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function. Journal of Experimental Medicine, 219 (3). ISSN 0022-1007

McCarthy, Cormac, O'Donnell, Cliona P, Kelly, Neil E Wrigley, O'Shea, Donal and Hogan, Andrew E. (2021) COVID-19 severity and obesity: are MAIT cells a factor? The Lancet Respiratory Medicine, 9 (5). pp. 445-447. ISSN 2213-2600

Kedia-Mehta, Nidhi, Tobin, Laura, Zaiatz-Bittencourt, Vanessa, Pisarska, Marta M., De Barra, Conor, Choi, Chloe, Elamin, Einas, O’Shea, Donal, Gardiner, Clair M., Finlay, David K. and Hogan, Andrew E. (2021) Cytokine-induced natural killer cell training is dependent on cellular metabolism and is defective in obesity. Blood Advances, 5 (21). pp. 4447-4455. ISSN 2473-9529

Moynagh, Paul N. and Hogan, Andrew E. (2021) The IRX(3)some factor in macrophages. Nature Immunology, 22 (10). pp. 1203-1204. ISSN 1529-2908

O’Neill, Chloe, Cassidy, Féaron C., O’Shea, Donal and Hogan, Andrew E. (2021) Mucosal Associated Invariant T Cells in Cancer-Friend or Foe? Cancers, 13 (1582). pp. 1-11. ISSN 2072-6694

Naughton, Michelle, Moffatt, Jill, Eleftheriadis, George, de la Vega Gallardo, Nira, Young, Andrew, Hawkins, Kristen, Pearson, Ben, Perbal, Bernard, Hogan, Andrew E., Moynagh, Paul N., Loveless, Sam, Robertson, Neil P., Gran, Bruno, Kee, Rachael, Hughes, Stella, McDonnell, Gavin, Howell, Owain and Fitzgerald, Denise C. (2020) CCN3 is dynamically regulated by treatment and disease state in multiple sclerosis. Journal of Neuroinflammation, 17 (349). pp. 1-13. ISSN 1742-2094

Pisarska, Marta M., Dunne, Margaret R., O'Shea, Donal and Hogan, Andrew E. (2020) Interleukin‐17 producing mucosal associated invariant T cells ‐ emerging players in chronic inflammatory diseases? European Journal of Immunology, 50 (8). pp. 1098-1108. ISSN 0014-2980

Harns, Emily, Roberts, Joseph, Bermingham, Rachel, Hogan, Andrew E., O'Shea, Donal, O'Neill, Luke and Fallon, Padraic G. (2020) Role for Retinoic Acid-Related Orphan Receptor Alpha (RORα) Expressing Macrophages in Diet-Induced Obesity. Frontiers in Immunology, 11 (1966). pp. 1-13. ISSN 1664-3224

Brien, Aisling O’, Kedia-Mehta, Nidhi, Tobin, Laura, Veerapen, Natacha, Besra, Gurdyal S., Shea, Donal O’ and Hogan, Andrew E. (2020) Targeting mitochondrial dysfunction in MAIT cells limits IL-17 production in obesity. Cellular & Molecular Immunology, 17 (11). pp. 1193-1195. ISSN 1672-7681

O'Shea, Donal and Hogan, Andrew E. (2019) Dysregulation of Natural Killer Cells in Obesity. Cancers, 11 (4). ISSN 2072-6694

Giannoudaki, Eirini, Hernandez-Santana, Yasmina E., Mulfaul, Kelly, Doyle, Sarah L., Hams, Emily, Fallon, Padraic G., Mat, Arimin, O'Shea, Donal, Kopf, Manfred, Hogan, Andrew E. and Walsh, Patrick T. (2019) Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction. Nature Communications, 10 (4003). ISSN 2041-1723

Melo, Ashanty M., O'Brien, Aisling M., Phelan, James J., Kennedy, Susan A., Wood, Nicole A.W., Veerapen, Natacha, Besra, Gurdyal S., Clarke, Niamh E., Foley, Emma K., Ravi, Akshaya, MacCarthy, Finbar, O'Toole, Dermot, Ravi, Narayamasami, Reynolds, John V., Conroy, Melissa J., Hogan, Andrew E., O'Sullivan, Jacintha and Dunne, Margaret R. (2019) Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma. Frontiers in Immunology, 10 (1580). ISSN 1664-3224

Tobin, Laura M., Mavinkurve, Meena, Carolan, Eirin, Kinlen, David, O'Brien, Eoin C., Little, Mark A., Finlay, David K., Cody, Declan, Hogan, Andrew E. and O'Shea, Donal (2019) NK cells in childhood obesity are activated, metabolically stressed, and functionally deficient. JCI Insight, 2 (24). e94939. ISSN 2379-3708

Brennan, Kiva, O'Leary, Bobby D., McLaughlin, Danielle, Kinlen, David, Molloy, Eleanor J., Cody, Declan, Paran, Sri, McAuliffe, Fionnuala M., Hogan, Andrew E. and Doyle, Sarah L. (2019) Nucleic acid cytokine responses in obese children and infants of obese mothers. Cytokine. pp. 152-158. ISSN 1043-4666

O'Brien, Aisling, Loftus, Roisin M., Pisarska, Marta M., Tobin, Laura M., Bergin, Ronan, Wood, Nicole A.W., Foley, Cathriona, Mat, Arimin, Tinley, Frances C., Bannan, Ciaran, Sommerville, Gary, Veerapen, Natacha, Besra, Gurdyal S., Sinclair, Linda V., Moynagh, Paul N., Lynch, Lydia, Finlay, David K., O'Shea, Donal and Hogan, Andrew E. (2019) Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses. Journal of Immunology, 202. pp. 3404-3411. ISSN 0022-1767

Michelet, Xavier, Dyck, Lydia, Hogan, Andrew E., Loftus, Roisin, Duquette, Danielle, Wei, Kevin, Beyaz, Semir, Tavakkoli, Ali, Foley, Cathriona, Donnelly, Raymond, O'Farrelly, Cliona, Raverdeau, Mathilde, Veron, Ashley, Pettee, William, O'Shea, Donal, Nikolajczyk, Barbara S, Mills, Kingston H.G., Brenner, Michael B., Finlay, David and Lynch, Lydia (2018) Metabolic reprogramming of natural killer cells in obesity limits antitumor responses. Nature Immunology, 19. pp. 1330-1340. ISSN 1529-2908

Brennan, Kiva, O'Leary, Bobby D., McLaughlin, Danielle, Breen, Eamon P., Connolly, Emma, Ali, Nusrat, O'Driscoll, David N., Ozaki, Ema, Mahony, Rebecca, Mulfaul, Kelly, Ryan, Aoife M., Ni Chianain, Aine, McHugh, Alison, Molloy, Eleanor J., Hogan, Andrew E., Paran, Sri, McAuliffe, Fionnuala M. and Doyle, Sarah L. (2018) Type 1 IFN Induction by Cytosolic Nucleic Acid Is Intact in Neonatal Mononuclear Cells, Contrasting Starkly with Neonatal Hyporesponsiveness to TLR Ligation Due to Independence from Endosome-Mediated IRF3 Activation. Journal of Immunology, 201. pp. 1131-1143. ISSN 0022-1767

Khan, Faheem, Mat, Arimin, Hogan, Andrew E., Kent, Brian D., Eigenheer, Sonia, Corrigan, Michelle, O'Shea, Donal and Butler, Marcus W. (2017) Preliminary asthma-related outcomes following glucagon-like peptide 1 agonist therapy. QJM: An International Journal of Medicine, 110 (12). pp. 853-854. ISSN 1460-2725

Boulenouar, Selma, Michelet, Xavier, Duquette, Danielle, Alvarez, Daniel, Hogan, Andrew E., Dold, Christina, O’Connor, Donal, Stutte, Suzanne, Tavakkoli, Ali, Winters, Desmond, Exley, Mark A., O'Shea, Donal, Brenner, Michael B., von Andrian, Ulrich and Lynch, Lydia (2017) Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity. Immunity, 46 (2). pp. 273-286. ISSN 1097-4180

Hams, Emily, Bermingham, Rachel, Wurlod, Felicity A., Hogan, Andrew E., O'Shea, Donal, Preston, Roger J., Rodewald, Hans-Reimer, McKenzie, Andrew N.J. and Fallon, Padraic G. (2016) The helminth T2 RNase v1 promotes metabolic homeostasis in an IL-33– and group 2 innate lymphoid cell–dependent mechanism. The FASEB Journal, 30. pp. 824-835. ISSN 0892-6638

Lynch, Lydia, Hogan, Andrew E., Duquette, Danielle, O'Shea, Donal and Brenner, Michael B. (2016) iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy. Cell Metabolism, 24. pp. 510-519. ISSN 1550-4131

Carolan, Eirin, Tobin, Laura M., Mangan, Bozgana A., Corrigan, Michelle, Gaoatswe, Gadintshware, Byrne, Greg, Geoghegan, Justin, Cody, Declan, O'Connell, Jean, Winter, Desmond C, Doherty, Derek G., Lynch, Lydia, O'Shea, Donal and Hogan, Andrew E. (2015) Altered Distribution and Increased IL-17 Production by Mucosal-Associated Invariant T Cells in Adult and Childhood Obesity. Journal of Immunology, 194 (12). pp. 5775-5780. ISSN 0022-1767

Gaoatswe, Gadintshware, Kent, Brian D., Corrigan, Michelle, Nolan, Geraldine, Hogan, Andrew E., McNicholas, Walter and O'Shea, Donal (2015) Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity. Sleep, 38 (10). pp. 1629-1634. ISSN 0161-8105

Woods, Conor, Corrigan, Michelle, Gathercole, L., Taylor, A., Hughes, B., Gaoatswe, Gadintshware, Manolopoulos, K., Hogan, Andrew E., O'Connell, Jean, Stewart, P.M., Tomlinson, J.W., O'Shea, Donal and Sherlock, M. (2015) Tissue Specific Regulation of Glucocorticoids in Severe Obesity and the Response to Significant Weight Loss Following Bariatric Surgery (BARICORT). Journal of Clinical Endocrinology and Metabolism, 100 (4). pp. 1434-1444. ISSN 0021-972X

Yang, Shuo, Wang, Bingwei, Humphries, Fiachra, Hogan, Andrew E., O'Shea, Donal and Moynagh, Paul N. (2014) The E3 Ubiquitin Ligase Pellino3 Protects against Obesity-Induced Inflammation and Insulin Resistance. Immunity, 41 (6). ISSN 1097-4180

Hogan, Andrew E., Gaoatswe, Gadintshware, Lynch, Lydia, Corrigan, Michelle, Woods, Conor, O'Connell, Jean and O'Shea, Donal (2014) Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus. Diabetologia, 57. pp. 781-784. ISSN 0012-186X

Carolan, Eirin, Hogan, Andrew E., Corrigan, Michelle, Gaotswe, Gadintshware, O'Connell, Jean, Foley, Niamh, O'Neill, Luke A., Cody, Declan and O'Shea, Donal (2014) The Impact of Childhood Obesity on Inflammation, Innate Immune Cell Frequency, and Metabolic MicroRNA Expression. Journal of Clinical Endocrinology and Metabolism, 99 (3). pp. 474-478. ISSN 0021-972X

O'Shea, Donal, Corrigan, Michelle, Dunne, Margaret R., Jackson, Ruaidhri, Woods, Conor, Gaoatswe, Gadintshware, Moynagh, Paul N., O'Connell, Jean and Hogan, Andrew E. (2013) Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection. International Journal of Obesity, 37 (11). pp. 1510-1513. ISSN 0307-0565

Mangan, Bozgana A., Dunne, Margaret R., O'Reilly, Vincent P., Dunne, Padraic J., Exley, Mark A., O'Shea, Donal, Schotet, Emmanuel, Hogan, Andrew E. and Doherty, Derek G. (2013) Cutting Edge: CD1d Restriction and Th1/Th2/Th17 Cytokine Secretion by Human Vδ3 T Cells. Journal of Immunology, 191 (1). pp. 30-34. ISSN 0022-1767

Zeng, Shijuan G., Ghnewa, Yasmeen G., O'Reilly, Vincent P., Lyons, Victoria G., Atzberger, Ann, Hogan, Andrew E., Exley, Mark A. and Doherty, Derek G. (2013) Human Invariant NKT Cell Subsets Differentially Promote Differentiation, Antibody Production, and T Cell Stimulation by B Cells In Vitro. Journal of Immunology, 191 (4). pp. 1666-1676. ISSN 0022-1767

Lynch, Lydia, Nowak, Michael, Varghese, Bindu, Clark, Justice, Hogan, Andrew E., Toxavidis, Vasillis, Balk, Steven P., O'Shea, Donal, O'Farrelly, Cliona and Exley, Mark A. (2012) Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production. Immunity, 37 (3). pp. 574-587. ISSN 1097-4180

Farah, Nadine, Hogan, Andrew E., O'Connor, Norah, Kennelly, Mairead M., O'Shea, Donal and Turner, Michael J. (2012) Correlation between maternal inflammatory markers and fetomaternal adiposity. Cytokine, 60 (1). pp. 96-99. ISSN 1043-4666

Hogan, Andrew E., O'Reilly, Vincent P., Dunne, Margaret R., Dere, Ravindra T., Zeng, Shijuan G., O'Brien, Cashel, Amu, Sylvie, Fallon, Padraic G., Exley, Mark A., O'Farrelly, Cliona, Zhu, Xiangming and Doherty, Derek G. (2011) Activation of human invariant natural killer T cells with a thioglycoside analogue of α-galactosylceramide. Clinical Immunology, 140 (2). pp. 196-207. ISSN 1521-6616

Hogan, Andrew E., Corrigan, Michelle, O'Reilly, Vincent P., Gaoatswe, G., O'Connell, Jean, Doherty, Derek G., Lynch, Lydia and O'Shea, Donal (2011) Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses. Clinical Immunology, 140. pp. 229-235. ISSN 1521-6616

O'Reilly, Vincent P., Zeng, Shijuan G., Bricard, Gabriel, Atzberger, Ann, Hogan, Andrew E., Jackson, John, Feighery, Conleth, Porcelli, Steven A. and Doherty, Derek G. (2011) Distinct and Overlapping Effector Functions of Expanded Human CD4+, CD8α+ and CD4-CD8α- Invariant Natural Killer T Cells. PLoS ONE, 6 (12). e28648. ISSN 1932-6203

Hogan, Andrew E., Tobin, A.M., Ahern, T., Corrigan, Michelle, Gaoatswe, Gadintshware, Jackson, Ruaidhri, O’Reilly, Vincent P., Lynch, Lydia, Doherty, D.G., Moynagh, Paul N., Kirby, B., O’Connell, Jean and O'Shea, Donal (2011) Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer Tcells: lessons from obesity, diabetes and psoriasis. Diabetologia, 54 (11). pp. 2745-2754. ISSN 0012-186X

Michielsen, Adriana J., Hogan, Andrew E., Marry, Joseph, Tosetto, Miriam, Cox, Fionnuala, Hyland, John M., Sheahan, Kieran, O'Donoghue, Diarmuid, Mulcahy, Hugh E., Ryan, Elizabeth J. and O'Sullivan, Jacintha N. (2011) Tumour Tissue Microenvironment Can Inhibit Dendritic Cell Maturation in Colorectal Cancer. PLoS ONE, 6 (11). e27944. ISSN 1932-6203

Kenna, Tony, O'Brien, Margaret, Hogan, Andrew E., Exley, Mark A., Porcelli, Steven A., Hegarty, John E., O'Farrelly, Cliona and Doherty, Derek G. (2007) CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver. Cancer Immunology, Immunotherapy, 56 (4). pp. 563-572. ISSN 1432-0851

Thesis

Hogan, Andrew E. (2010) Characterisation of the immunomodulatory properties of human natural killer T cells. PhD thesis, National University of Ireland Maynooth.