Article

Ryan, Eimear K. and Clutter, Christy and De Barra, Conor and Jenkins, Benjamin J. and O’Shaughnessy, Simon and Ryan, Odhrán K. and McKenna, Chloe and Heneghan, Helen M. and Walsh, Fiona and Finlay, David K. and Sinclair, Linda V. and Jones, Nicholas and Leung, Daniel T. and O’Shea, Donal and Hogan, Andrew E. (2024) Iron Is Critical for Mucosal-Associated Invariant T Cell Metabolism and Effector Functions. The Journal of Immunology. ISSN 0022-1767

Ryan, Eimear K. and Clutter, Christy and De Barra, Conor and Jenkins, Benjamin J. and O’Shaughnessy, Simon and Ryan, Odhrán K. and McKenna, Chloe and Heneghan, Helen M. and Walsh, Fiona and Finlay, David K. and Sinclair, Linda V. and Jones, Nicholas and Leung, Daniel T. and O’Shea, Donal and Hogan, Andrew E. (2024) Iron Is Critical for Mucosal-Associated Invariant T Cell Metabolism and Effector Functions. The Journal of Immunology, 212 (11). pp. 1706-1713. ISSN 0022-1767

Cassidy, Féaron C. and Kedia-Mehta, Nidhi and Bergin, Ronan and Woodcock, Andrea and Berisha, Ardena and Bradley, Ben and Booth, Eva and Jenkins, Benjamin J. and Ryan, Odhrán K. and Jones, Nicholas and Sinclair, Linda V. and O’Shea, Donal and Hogan, Andrew E. (2023) Glycogen-fuelled metabolism supports rapid mucosal-associated invariant T cell responses. Proceedings of the National Academy of Sciences, 120 (25). ISSN 1091-6490

Gallagher, Catriona and Mahon, Julie Mac and O’Neill, Chloe and Cassidy, Féaron C. and Dunbar, Hazel and De Barra, Conor and Cadden, Caoimhe and Pisarska, Marta M. and Wood, Nicole and Masterson, Joanne C. and McNamee, Eoin N. and English, Karen and O’Shea, Donal and Tobin, Anne Marie and Hogan, Andrew E. (2023) Mucosal associated invariant T cells are altered in patients with Hidradenitis Suppurativa and contribute to the inflammatory milieu. Journal of Investigative Dermatology, 143 (6). pp. 1094-1097. ISSN 0022-202X

Cooper, Andrew J. R. and Clegg, Jonah and Cassidy, Féaron C. and Hogan, Andrew E. and McLoughlin, Rachel M. (2022) Human MAIT Cells Respond to Staphylococcus aureus with Enhanced Anti-Bacterial Activity. Microorganisms, 10 (148). pp. 1-19. ISSN 2076-2607

Wrigley Kelly, Neil E. and Kenny, Grace and Cassidy, Féaron C. and Garcia‐Leon, Alejandro A. and De Barra, Conor and Mallon, Patrick W. G. and Hogan, Andrew E. and O'Shea, Donal (2022) Individuals with obesity who survive SARS‐CoV‐2 infection have preserved antigen‐specific T cell frequencies. Obesity, 30 (10). pp. 1927-1931. ISSN 1930-7381

Schwartz, Christian and Schmidt, Viviane and Deinzer, Andrea and Hawerkamp, Heike C. and Hams, Emily and Bayerlein, Jasmin and Röger, Ole and Bailer, Moritz and Krautz, Christian and El Gendy, Amr and Elshafei, Moustafa and Heneghan, Helen M. and Hogan, Andrew E. and O’Shea, Donal and Fallon, Padraic G. (2022) Innate PD-L1 limits T cell–mediated adipose tissue inflammation and ameliorates diet-induced obesity. Science Translational Medicine, 14 (635). ISSN 1946-6234

Dyck, Lydia and Prendeville, Hannah and Raverdeau, Mathilde and Wilk, Mieszko M. and Loftus, Roisin M. and Douglas, Aaron and McCormack, Janet and Moran, Bruce and Wilkinson, Michael and Mills, Evanna L. and Doughty, Michael and Fabre, Aurelie and Heneghan, Helen and LeRoux, Carel and Hogan, Andrew E. and Chouchani, Edward T. and O’Shea, Donal and Brennan, Donal and Lynch, Lydia (2022) Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function. Journal of Experimental Medicine, 219 (3). ISSN 0022-1007

McCarthy, Cormac and O'Donnell, Cliona P and Kelly, Neil E Wrigley and O'Shea, Donal and Hogan, Andrew E. (2021) COVID-19 severity and obesity: are MAIT cells a factor? The Lancet Respiratory Medicine, 9 (5). pp. 445-447. ISSN 2213-2600

Kedia-Mehta, Nidhi and Tobin, Laura and Zaiatz-Bittencourt, Vanessa and Pisarska, Marta M. and De Barra, Conor and Choi, Chloe and Elamin, Einas and O’Shea, Donal and Gardiner, Clair M. and Finlay, David K. and Hogan, Andrew E. (2021) Cytokine-induced natural killer cell training is dependent on cellular metabolism and is defective in obesity. Blood Advances, 5 (21). pp. 4447-4455. ISSN 2473-9529

Moynagh, Paul N. and Hogan, Andrew E. (2021) The IRX(3)some factor in macrophages. Nature Immunology, 22 (10). pp. 1203-1204. ISSN 1529-2908

O’Neill, Chloe and Cassidy, Féaron C. and O’Shea, Donal and Hogan, Andrew E. (2021) Mucosal Associated Invariant T Cells in Cancer-Friend or Foe? Cancers, 13 (1582). pp. 1-11. ISSN 2072-6694

Naughton, Michelle and Moffatt, Jill and Eleftheriadis, George and de la Vega Gallardo, Nira and Young, Andrew and Hawkins, Kristen and Pearson, Ben and Perbal, Bernard and Hogan, Andrew E. and Moynagh, Paul N. and Loveless, Sam and Robertson, Neil P. and Gran, Bruno and Kee, Rachael and Hughes, Stella and McDonnell, Gavin and Howell, Owain and Fitzgerald, Denise C. (2020) CCN3 is dynamically regulated by treatment and disease state in multiple sclerosis. Journal of Neuroinflammation, 17 (349). pp. 1-13. ISSN 1742-2094

Pisarska, Marta M. and Dunne, Margaret R. and O'Shea, Donal and Hogan, Andrew E. (2020) Interleukin‐17 producing mucosal associated invariant T cells ‐ emerging players in chronic inflammatory diseases? European Journal of Immunology, 50 (8). pp. 1098-1108. ISSN 0014-2980

Harns, Emily and Roberts, Joseph and Bermingham, Rachel and Hogan, Andrew E. and O'Shea, Donal and O'Neill, Luke and Fallon, Padraic G. (2020) Role for Retinoic Acid-Related Orphan Receptor Alpha (RORα) Expressing Macrophages in Diet-Induced Obesity. Frontiers in Immunology, 11 (1966). pp. 1-13. ISSN 1664-3224

Brien, Aisling O’ and Kedia-Mehta, Nidhi and Tobin, Laura and Veerapen, Natacha and Besra, Gurdyal S. and Shea, Donal O’ and Hogan, Andrew E. (2020) Targeting mitochondrial dysfunction in MAIT cells limits IL-17 production in obesity. Cellular & Molecular Immunology, 17 (11). pp. 1193-1195. ISSN 1672-7681

O'Shea, Donal and Hogan, Andrew E. (2019) Dysregulation of Natural Killer Cells in Obesity. Cancers, 11 (4). ISSN 2072-6694

Giannoudaki, Eirini and Hernandez-Santana, Yasmina E. and Mulfaul, Kelly and Doyle, Sarah L. and Hams, Emily and Fallon, Padraic G. and Mat, Arimin and O'Shea, Donal and Kopf, Manfred and Hogan, Andrew E. and Walsh, Patrick T. (2019) Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction. Nature Communications, 10 (4003). ISSN 2041-1723

Melo, Ashanty M. and O'Brien, Aisling M. and Phelan, James J. and Kennedy, Susan A. and Wood, Nicole A.W. and Veerapen, Natacha and Besra, Gurdyal S. and Clarke, Niamh E. and Foley, Emma K. and Ravi, Akshaya and MacCarthy, Finbar and O'Toole, Dermot and Ravi, Narayamasami and Reynolds, John V. and Conroy, Melissa J. and Hogan, Andrew E. and O'Sullivan, Jacintha and Dunne, Margaret R. (2019) Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma. Frontiers in Immunology, 10 (1580). ISSN 1664-3224

Tobin, Laura M. and Mavinkurve, Meena and Carolan, Eirin and Kinlen, David and O'Brien, Eoin C. and Little, Mark A. and Finlay, David K. and Cody, Declan and Hogan, Andrew E. and O'Shea, Donal (2019) NK cells in childhood obesity are activated, metabolically stressed, and functionally deficient. JCI Insight, 2 (24). e94939. ISSN 2379-3708

Brennan, Kiva and O'Leary, Bobby D. and McLaughlin, Danielle and Kinlen, David and Molloy, Eleanor J. and Cody, Declan and Paran, Sri and McAuliffe, Fionnuala M. and Hogan, Andrew E. and Doyle, Sarah L. (2019) Nucleic acid cytokine responses in obese children and infants of obese mothers. Cytokine. pp. 152-158. ISSN 1043-4666

O'Brien, Aisling and Loftus, Roisin M. and Pisarska, Marta M. and Tobin, Laura M. and Bergin, Ronan and Wood, Nicole A.W. and Foley, Cathriona and Mat, Arimin and Tinley, Frances C. and Bannan, Ciaran and Sommerville, Gary and Veerapen, Natacha and Besra, Gurdyal S. and Sinclair, Linda V. and Moynagh, Paul N. and Lynch, Lydia and Finlay, David K. and O'Shea, Donal and Hogan, Andrew E. (2019) Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses. Journal of Immunology, 202. pp. 3404-3411. ISSN 0022-1767

Michelet, Xavier and Dyck, Lydia and Hogan, Andrew E. and Loftus, Roisin and Duquette, Danielle and Wei, Kevin and Beyaz, Semir and Tavakkoli, Ali and Foley, Cathriona and Donnelly, Raymond and O'Farrelly, Cliona and Raverdeau, Mathilde and Veron, Ashley and Pettee, William and O'Shea, Donal and Nikolajczyk, Barbara S and Mills, Kingston H.G. and Brenner, Michael B. and Finlay, David and Lynch, Lydia (2018) Metabolic reprogramming of natural killer cells in obesity limits antitumor responses. Nature Immunology, 19. pp. 1330-1340. ISSN 1529-2908

Brennan, Kiva and O'Leary, Bobby D. and McLaughlin, Danielle and Breen, Eamon P. and Connolly, Emma and Ali, Nusrat and O'Driscoll, David N. and Ozaki, Ema and Mahony, Rebecca and Mulfaul, Kelly and Ryan, Aoife M. and Ni Chianain, Aine and McHugh, Alison and Molloy, Eleanor J. and Hogan, Andrew E. and Paran, Sri and McAuliffe, Fionnuala M. and Doyle, Sarah L. (2018) Type 1 IFN Induction by Cytosolic Nucleic Acid Is Intact in Neonatal Mononuclear Cells, Contrasting Starkly with Neonatal Hyporesponsiveness to TLR Ligation Due to Independence from Endosome-Mediated IRF3 Activation. Journal of Immunology, 201. pp. 1131-1143. ISSN 0022-1767

Khan, Faheem and Mat, Arimin and Hogan, Andrew E. and Kent, Brian D. and Eigenheer, Sonia and Corrigan, Michelle and O'Shea, Donal and Butler, Marcus W. (2017) Preliminary asthma-related outcomes following glucagon-like peptide 1 agonist therapy. QJM: An International Journal of Medicine, 110 (12). pp. 853-854. ISSN 1460-2725

Boulenouar, Selma and Michelet, Xavier and Duquette, Danielle and Alvarez, Daniel and Hogan, Andrew E. and Dold, Christina and O’Connor, Donal and Stutte, Suzanne and Tavakkoli, Ali and Winters, Desmond and Exley, Mark A. and O'Shea, Donal and Brenner, Michael B. and von Andrian, Ulrich and Lynch, Lydia (2017) Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity. Immunity, 46 (2). pp. 273-286. ISSN 1097-4180

Hams, Emily and Bermingham, Rachel and Wurlod, Felicity A. and Hogan, Andrew E. and O'Shea, Donal and Preston, Roger J. and Rodewald, Hans-Reimer and McKenzie, Andrew N.J. and Fallon, Padraic G. (2016) The helminth T2 RNase v1 promotes metabolic homeostasis in an IL-33– and group 2 innate lymphoid cell–dependent mechanism. The FASEB Journal, 30. pp. 824-835. ISSN 0892-6638

Lynch, Lydia and Hogan, Andrew E. and Duquette, Danielle and O'Shea, Donal and Brenner, Michael B. (2016) iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy. Cell Metabolism, 24. pp. 510-519. ISSN 1550-4131

Carolan, Eirin and Tobin, Laura M. and Mangan, Bozgana A. and Corrigan, Michelle and Gaoatswe, Gadintshware and Byrne, Greg and Geoghegan, Justin and Cody, Declan and O'Connell, Jean and Winter, Desmond C and Doherty, Derek G. and Lynch, Lydia and O'Shea, Donal and Hogan, Andrew E. (2015) Altered Distribution and Increased IL-17 Production by Mucosal-Associated Invariant T Cells in Adult and Childhood Obesity. Journal of Immunology, 194 (12). pp. 5775-5780. ISSN 0022-1767

Gaoatswe, Gadintshware and Kent, Brian D. and Corrigan, Michelle and Nolan, Geraldine and Hogan, Andrew E. and McNicholas, Walter and O'Shea, Donal (2015) Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity. Sleep, 38 (10). pp. 1629-1634. ISSN 0161-8105

Woods, Conor and Corrigan, Michelle and Gathercole, L. and Taylor, A. and Hughes, B. and Gaoatswe, Gadintshware and Manolopoulos, K. and Hogan, Andrew E. and O'Connell, Jean and Stewart, P.M. and Tomlinson, J.W. and O'Shea, Donal and Sherlock, M. (2015) Tissue Specific Regulation of Glucocorticoids in Severe Obesity and the Response to Significant Weight Loss Following Bariatric Surgery (BARICORT). Journal of Clinical Endocrinology and Metabolism, 100 (4). pp. 1434-1444. ISSN 0021-972X

Yang, Shuo and Wang, Bingwei and Humphries, Fiachra and Hogan, Andrew E. and O'Shea, Donal and Moynagh, Paul N. (2014) The E3 Ubiquitin Ligase Pellino3 Protects against Obesity-Induced Inflammation and Insulin Resistance. Immunity, 41 (6). ISSN 1097-4180

Hogan, Andrew E. and Gaoatswe, Gadintshware and Lynch, Lydia and Corrigan, Michelle and Woods, Conor and O'Connell, Jean and O'Shea, Donal (2014) Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus. Diabetologia, 57. pp. 781-784. ISSN 0012-186X

Carolan, Eirin and Hogan, Andrew E. and Corrigan, Michelle and Gaotswe, Gadintshware and O'Connell, Jean and Foley, Niamh and O'Neill, Luke A. and Cody, Declan and O'Shea, Donal (2014) The Impact of Childhood Obesity on Inflammation, Innate Immune Cell Frequency, and Metabolic MicroRNA Expression. Journal of Clinical Endocrinology and Metabolism, 99 (3). pp. 474-478. ISSN 0021-972X

O'Shea, Donal and Corrigan, Michelle and Dunne, Margaret R. and Jackson, Ruaidhri and Woods, Conor and Gaoatswe, Gadintshware and Moynagh, Paul N. and O'Connell, Jean and Hogan, Andrew E. (2013) Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection. International Journal of Obesity, 37 (11). pp. 1510-1513. ISSN 0307-0565

Mangan, Bozgana A. and Dunne, Margaret R. and O'Reilly, Vincent P. and Dunne, Padraic J. and Exley, Mark A. and O'Shea, Donal and Schotet, Emmanuel and Hogan, Andrew E. and Doherty, Derek G. (2013) Cutting Edge: CD1d Restriction and Th1/Th2/Th17 Cytokine Secretion by Human Vδ3 T Cells. Journal of Immunology, 191 (1). pp. 30-34. ISSN 0022-1767

Zeng, Shijuan G. and Ghnewa, Yasmeen G. and O'Reilly, Vincent P. and Lyons, Victoria G. and Atzberger, Ann and Hogan, Andrew E. and Exley, Mark A. and Doherty, Derek G. (2013) Human Invariant NKT Cell Subsets Differentially Promote Differentiation, Antibody Production, and T Cell Stimulation by B Cells In Vitro. Journal of Immunology, 191 (4). pp. 1666-1676. ISSN 0022-1767

Lynch, Lydia and Nowak, Michael and Varghese, Bindu and Clark, Justice and Hogan, Andrew E. and Toxavidis, Vasillis and Balk, Steven P. and O'Shea, Donal and O'Farrelly, Cliona and Exley, Mark A. (2012) Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production. Immunity, 37 (3). pp. 574-587. ISSN 1097-4180

Farah, Nadine and Hogan, Andrew E. and O'Connor, Norah and Kennelly, Mairead M. and O'Shea, Donal and Turner, Michael J. (2012) Correlation between maternal inflammatory markers and fetomaternal adiposity. Cytokine, 60 (1). pp. 96-99. ISSN 1043-4666

Hogan, Andrew E. and O'Reilly, Vincent P. and Dunne, Margaret R. and Dere, Ravindra T. and Zeng, Shijuan G. and O'Brien, Cashel and Amu, Sylvie and Fallon, Padraic G. and Exley, Mark A. and O'Farrelly, Cliona and Zhu, Xiangming and Doherty, Derek G. (2011) Activation of human invariant natural killer T cells with a thioglycoside analogue of α-galactosylceramide. Clinical Immunology, 140 (2). pp. 196-207. ISSN 1521-6616

Hogan, Andrew E. and Corrigan, Michelle and O'Reilly, Vincent P. and Gaoatswe, G. and O'Connell, Jean and Doherty, Derek G. and Lynch, Lydia and O'Shea, Donal (2011) Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses. Clinical Immunology, 140. pp. 229-235. ISSN 1521-6616

O'Reilly, Vincent P. and Zeng, Shijuan G. and Bricard, Gabriel and Atzberger, Ann and Hogan, Andrew E. and Jackson, John and Feighery, Conleth and Porcelli, Steven A. and Doherty, Derek G. (2011) Distinct and Overlapping Effector Functions of Expanded Human CD4+, CD8α+ and CD4-CD8α- Invariant Natural Killer T Cells. PLoS ONE, 6 (12). e28648. ISSN 1932-6203

Hogan, Andrew E. and Tobin, A.M. and Ahern, T. and Corrigan, Michelle and Gaoatswe, Gadintshware and Jackson, Ruaidhri and O’Reilly, Vincent P. and Lynch, Lydia and Doherty, D.G. and Moynagh, Paul N. and Kirby, B. and O’Connell, Jean and O'Shea, Donal (2011) Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer Tcells: lessons from obesity, diabetes and psoriasis. Diabetologia, 54 (11). pp. 2745-2754. ISSN 0012-186X

Michielsen, Adriana J. and Hogan, Andrew E. and Marry, Joseph and Tosetto, Miriam and Cox, Fionnuala and Hyland, John M. and Sheahan, Kieran and O'Donoghue, Diarmuid and Mulcahy, Hugh E. and Ryan, Elizabeth J. and O'Sullivan, Jacintha N. (2011) Tumour Tissue Microenvironment Can Inhibit Dendritic Cell Maturation in Colorectal Cancer. PLoS ONE, 6 (11). e27944. ISSN 1932-6203

Kenna, Tony and O'Brien, Margaret and Hogan, Andrew E. and Exley, Mark A. and Porcelli, Steven A. and Hegarty, John E. and O'Farrelly, Cliona and Doherty, Derek G. (2007) CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver. Cancer Immunology, Immunotherapy, 56 (4). pp. 563-572. ISSN 1432-0851

Thesis

Hogan, Andrew E. (2010) Characterisation of the immunomodulatory properties of human natural killer T cells. PhD thesis, National University of Ireland Maynooth.