Article

Daumann, Lena J., Dalle, Kristian E., Schenk, Gerhard, McGeary, Ross P., Bernhardt, Paul V., Ollis, David L. and Gahan, Lawrence R. (2012) The role of Zn–OR and Zn–OH nucleophiles and the influence of para-substituents in the reactions of binuclear phosphatase mimetics. Dalton Transactions, 41. pp. 1695-1708. ISSN 1477-9226

Ugwumba, Isaac N., Ozawa, Kiyoshi, Xu, Zhi-Qiang, Ely, Fernanda, Foo, Jee-Loon , Herlt, Anthony J., Coppin, Chris, Brown, Sue, Taylor, Matthew C., Ollis, David L., Mander, Lewis N., Schenk, Gerhard, Dixon, Nicholas E., Otting, Gottfried, Oakeshott, John G. and Jackson, Colin J. (2011) Improving a Natural Enzyme Activity through Incorporation of Unnatural Amino Acids. Journal of the American Chemical Society, 133 (2). pp. 326-333. ISSN 0002-7863

Kantacha, Anob, Buchholz, Rebecca, Smith, Sarah J., Schenk, Gerhard and Gahan, Lawrence R. (2011) Phosphate ester cleavage promoted by a tetrameric iron(III) complex. Journal of Biological Inorganic Chemistry, 16 (1). pp. 23-32. ISSN 0949-8257

Ely, Fernanda, Hadler, Kieran S., Gahan, Lawrence R., Guddat, Luke W., Ollis, David L. and Schenk, Gerhard (2010) The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis. Biochemical Journal, 432 (3). pp. 565-573. ISSN 0264-6021

Mitic, Natasa, Hadler, Keiran S., Gahan, Lawrence R., Hengge, Alvan C. and Schenk, Gerhard (2010) The divalent metal ion in the active site of uteroferrin modulates substrate binding and catalysis. Journal of the American Chemical Society, 132 (20). pp. 7049-6054. ISSN 0002-7863

Neves, Ademir , Bortoluzzi, Adailton J., Jovito, Rafael, Peralta, Rosely A., de Souza, Bernardo, Szpoganicz, Bruno, Joussef, Antonio C., Terenzi, Hernan, Severino, Patricia C., Fischer, Franciele L., Schenk, Gerhard, Riley, Mark J., Smith, Sarah J. and Gahan, Lawrence R. (2010) Catalytic Promiscuity: Catecholase-like Activity and Hydrolytic DNA Cleavage Promoted by a Mixed-Valence FeIIIFeII Complex. Journal of the Brazilian Chemical Society, 21 (7). pp. 1201-1212. ISSN 0103-5053

Hadler, Kieran S., Mitic, Natasa, Yip, Sylvia Hsu-Chen, Gahan, Lawrence R., Ollis, David L., Schenk, Gerhard and Larrabee, James A. (2010) Electronic Structure Analysis of the Dinuclear Metal Center in the Bioremediator Glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes. Inorganic Chemistry, 49. pp. 2727-2734. ISSN 0020-1669

Peralta, Rosely A., Bortoluzzi, Adailton J., de Souza, Bernardo, Jovito, Rafael, Xavier, Fernando R., Couto, Ricardo A. A., Casellato, Annelise, Nome, Faruk, Dick, Andrew, Gahan, Lawrence R., Schenk, Gerhard, Hanson, Graeme R., de Paula, Flavia C. S., Pereira-Maia, Elene C., Machado, Sergio de P., Severino, Patricia C., Pich, Claus, Bortolotto, Tiago, Terenzi, Hernan, Castellano, Eduardo E., Neves, Ademir and Riley, Mark J. (2010) Electronic Structure and Spectro-Structural Correlations of FeIIIZnII Biomimetics for Purple Acid Phosphatases: Relevance to DNA Cleavage and Cytotoxic Activity. Inorganic Chemistry, 49. pp. 11421-11438. ISSN 0020-1669

Foo, Jee-Loon , Jackson, Colin J., Carr, Paul D., Kim, Hye-Kyung, Schenk, Gerhard, Gahan, Lawrence R. and Ollis, David L. (2010) Mutation of outer-shell residues modulates metal ion co-ordination strength in a metalloenzyme. Biochemistry Journal, 429. pp. 313-321.

Lessa, Josane A., Horn Jr., Adolfo, Bull, Erika S., Rocha, Michelle R., Benassi, Mario, Catharino, Rodrigo R., Eberlin, Marcos N., Casellato, Annelise, Noble, Christopher J., Hanson, Graeme R., Schenk, Gerhard, Silva, Giselle C., Antunes, O. A. C. and Fernandes, Christiane (2009) Catalase vs Peroxidase Activity of a Manganese(II) Compound: Identification of a Mn(III)-(μ-O)2-Mn(IV) Reaction Intermediate by Electrospray Ionization Mass Spectrometry and Electron Paramagnetic Resonance Spectroscopy. Inorganic Chemistry, 48 (10). pp. 4569-4579. ISSN 0020-1669

McGeary, Ross P., Vella, Peter, Mak, Jeffrey Y. W., Guddat, Luke W. and Schenk, Gerhard (2009) Inhibition of purple acid phosphatase with a-alkoxynaphthylmethylphosphonic acids. Bioorganic and Medicinal Chemistry Letters , 19. pp. 163-166. ISSN 0960-894X

Mitic, Natasa, Noble, Christopher J., Gahan, Lawrence R., Hanson, Graeme R. and Schenk, Gerhard (2009) Metal-Ion Mutagenesis: Conversion of a Purple Acid Phosphatase from Sweet Potato to a Neutral Phosphatase with the Formation of an Unprecedented Catalytically Competent MnIIMnII Active Site. Journal of the American Chemical Society, 131 (23). pp. 8173-8179. ISSN 0002-7863

Hadler, Kieran S., Mitic, Natasa, Ely, Fernanda, Hanson, Graeme R., Gahan, Lawrence R., Larrabee, James A., Ollis, David L. and Schenk, Gerhard (2009) Structural Flexibility Enhances the Reactivity of the Bioremediator Glycerophosphodiesterase by Fine-Tuning Its Mechanism of Hydrolysis. Journal of the American Chemical Society, 131 (33). pp. 11900-11908. ISSN 0002-7863

Smith, Sarah J., Riley, Mark J., Noble, Christopher J., Hanson, Graeme R., Stranger, Robert, Jayaratne, Vidura, Cavigliasso, German, Schenk, Gerhard and Gahan, Lawrence R. (2009) Structural and Catalytic Characterization of a Heterovalent Mn(II)Mn(III) Complex That Mimics Purple Acid Phosphatases. Inorganic Chemistry, 48. pp. 10036-10048. ISSN 0020-1669

Xavier, Fernando R., Neves, Ademir, Casellato, Annelise, Peralta, Rosaly A., Bortoluzzi, Adailton J., Szpoganicz, Bruno, Severino, Patricia C., Terenzi, Hernan, Tomkowicz, Zbigniew , Haase, Wolfgang, Ozarowski, Andrew, Krzystek, Jerzy , Telser, Joshua, Schenk, Gerhard and Gahan, Lawrence R. (2009) Unsymmetrical FeIIICoII and GaIIICoII Complexes as Chemical Hydrolases: Biomimetic Models for Purple Acid Phosphatases (PAPs). Inorganic Chemistry, 48. pp. 7905-7091. ISSN 0020-1669

Hadler, Kieran S., Huber, Thomas, Cassady, A. Ian, Weber, Jane, Robinson, Jodie, Burrows, Allan, Kelly, Gregory, Guddat, Luke W., Hume, David A., Schenk, Gerhard and Flanagan, Jack U. (2008) Identification of a non-purple tartrate-resistant acid phosphatase: an evolutionary link to Ser/Thr protein phosphatases? BMC Research Notes, 1 (78). pp. 1-8. ISSN 1756-0500

Jackson, Colin J., Hadler, Kieran S., Carr, Paul D., Oakley, Aaron J., Yip, Sylvia, Schenk, Gerhard and Ollis, David L. (2008) Malonate-bound structure of the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) and characterization of the native Fe2+ metal-ion preference. Acta Crystallographica Section F, 64 (8). pp. 681-685. ISSN 1744-3091

Schenk, Gerhard, Elliott, Tristan W., Leung, Eleanor, Carrington, Lyle E., Mitic, Natasa, Gahan, Lawrence R. and Guddat, Luke W. (2008) Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle. BMC Structural Biology, 8 (6). doi:10.1186/1472-6807. ISSN 1472-6807

Buchholz, Rebecca, Etienne, Morgan E., Dorgelo, Anneke, Mirams, Ruth E., Smith, Sarah J., Chow, Shiao Yun, Hanton, Lyall R., Jameson, Geoffrey B., Schenk, Gerhard and Gahan, Lawrence R. (2008) A structural and catalytic model for zinc phosphoesterases. Dalton Transactions, 43. pp. 6045-6054. ISSN 1477-9226

Schenk, Gerhard, Peralta, Rosely A., Batista, Suzana Cimara, Bortoluzzi, Adailton J., Szpoganicz, Bruno, Dick, Andrew J., Herrald, Paul, Hanson, Graeme R., Szilagyi, Robert K., Riley, Mark J., Gahan, Lawrence R. and Neves, Ademir (2008) Probing the role of the divalent metal ion in uteroferrin using metal ion replacement and a comparison to isostructural biomimetics. Journal of Biological Inorganic Chemistry, 13 (1). pp. 139-155. ISSN 0949-8257

Smith, S. J., Noble, C. J., Palmer, R. C., Hanson, G. R., Schenk, Gerhard, Gahan, L. R. and Riley, M. J. (2008) Structural and spectroscopic studies of a model for catechol oxidase. Journal of Biological Inorganic Chemistry, 13 (4). pp. 499-510. ISSN 0949-8257

Hadler, Kieran S., Tanifum, Eric A., Hsu-Chen Yip, Sylvia, Mitic, Natasa, Guddat, Luke W., Jackson, Colin J., Gahan, Lawrence R., Nguyen, Kelly, Carr, Paul D., Ollis, David L., Hengge, Alvan C., Larrabee, James A. and Schenk, Gerhard (2008) Substrate-Promoted Formation of a Catalytically Competent Binuclear Center and Regulation of Reactivity in a Glycerophosphodiesterase from Enterobacter aerogenes. Journal of the American Chemical Society, 130 (43). pp. 14129-14138. ISSN 0002-7863

Neves, Ademir, Lanznaster, Mauricio, Bortoluzzi, Adailton J., Peralta, Rosely A., Casellato, Annelise, Castellano, Eduardo Ernesto, Herrald, Paul, Riley, Mark J. and Schenk, Gerhard (2007) An Unprecedented FeIII(μ-OH)ZnII Complex that Mimics the Structural and Functional Properties of Purple Acid Phosphatases. Journal of the American Chemical Society, 129 (24). pp. 7486-7487. ISSN 0002-7863

Cox, Robynn S., Schenk, Gerhard, Mitic, Natasa, Gahan, Lawrence R. and Hengge, Alvan C. (2007) Diesterase Activity and Substrate Binding in Purple Acid Phosphatases. Journal of the American Chemical Society, 129. pp. 9550-9551.

Neidig, Michael L., Wecksler, Aaron T., Schenk, Gerhard, Holman, Theodore R. and Solomon, Edward I. (2007) Kinetic and Spectroscopic Studies of N694C Lipoxygenase: A Probe of the Substrate Activation Mechanism of a Nonheme Ferric Enzyme. Journal of the American Chemical Society, 129. pp. 7531-7537. ISSN 0002-7863

Boudalis, Athanassios K., Aston, Robyn E., Smith, Sarah J., Mirams, Ruth E., Riley, Mark J., Schenk, Gerhard, Blackman, Allan G., Hanton, Lyall R. and Gahan, Lawrence R. (2007) Synthesis and characterization of the tetranuclear iron(III) complex of a new asymmetric multidentate ligand. A structural model for purple acid phosphatases. Dalton Transactions. pp. 5132-5139. ISSN 1477-9226

Liu, Jian-Wei, Hadler, Kieran S., Schenk, Gerhard and Ollis, David (2007) Using directed evolution to improve the solubility of the C-terminal domain of Escherichia coli aminopeptidase P Implications for metal binding and protein stability. The FEBS Journal, 274 (18). pp. 4742-4751. ISSN 1742-464X

Jackson, Colin J., Carr, Paul D., Kim, Hye-Kyung, Liu, Jian-Wei, Herrald, Paul, Mitic, Natasa, Schenk, Gerhard, Smith, Clyde A. and Ollis, David L. (2006) Anomalous scattering analysis of Agrobacterium radiobacter phosphotriesterase: the prominent role of iron in the heterobinuclear active site. Biochemical Journal, 397. pp. 501-508. ISSN 0264-6021

Elliott, Tristan W., Mitic, Natasa, Gahan, Lawrence R., Guddat, Luke W. and Schenk, Gerhard (2006) Inhibition Studies of Purple Acid Phosphatases: Implications for the Catalytic Mechanism. Journal of the Brazilian Chemical Society, 17 (8). pp. 1558-1565. ISSN 0103-5053

Mitic, Natasa, Smith, Sarah J., Neves, Ademir, Guddat, Luke W., Gahan, Lawrence R. and Schenk, Gerhard (2006) The Catalytic Mechanisms of Binuclear Metallohydrolases. Chemical Reviews, 106 (8). pp. 3338-3363. ISSN 0009-2665

Schenk, Gerhard, Gahan, Lawrence R., Carrington, Lyle E., Mitic, Natasa, Valizadeh, Mohsen, Hamilton, Susan E., de Jersey, John and Guddat, Luke W. (2005) Phosphate forms an unusual tripodal complex with the Fe–Mn center of sweet potato purple acid phosphatase. Proceedings of the National Academy of Sciences , 102 (2). pp. 273-278. ISSN 1091-6490

Lanznaster, Mauricio, Neves, Ademir, Bortoluzzi, Adailton J., Aires, Veronika V. E., Szpoganicz, Bruno, Terenzi, Hernan, Cardoso Severino, Patricia, Fuller, Julie M., Drew, Simon C., Gahan, Lawrence R., Hanson, Graeme R., Riley, Mark J. and Schenk, Gerhard (2005) A New Heterobinuclear FeIIICuII Complex with a Single Terminal FeIII–O(phenolate) Bond. Relevance to Purple Acid Phosphatases and Nucleases. Journal of Biological Inorganic Chemistry, 10 (4). pp. 319-332. ISSN 0949-8257

Lanznaster, Mauricio, Neves, Ademir, Bortoluzzi, Adailton J., Aires, Veronika V. E., Szpoganicz, Bruno, Terenzi, Hernan, Severino, Patricia C., Fuller, Julie M., Drew, Simon C., Gahan, Lawrence R., Hanson, Graeme R., Riley, Mark J. and Schenk, Gerhard (2005) A New Heterobinuclear FeIIICuII Complex with a Single Terminal FeIII–O(phenolate) Bond. Relevance to Purple Acid Phosphatases and Nucleases. Journal of Biological Inorganic Chemistry, 10 (4). pp. 319-332. ISSN 0949-8257

Schenk, Gerhard, Pau, Monita Y. M. and Solomon, Edward I. (2004) Comparison between the Geometric and Electronic Structures and Reactivities of {FeNO}7 and {FeO2}8 Complexes: A Density Functional Theory Study. Journal of the American Chemical Society, 126 (2). pp. 505-515. ISSN 0002-7863

Bernhardt, Paul V., Schenk, Gerhard and Wilson, Gregory J. (2004) Direct Electrochemistry of Porcine Purple Acid Phosphatase (Uteroferrin). Biochemistry, 43. pp. 10387-10392. ISSN 0006-2960

Valizadeh, Mohsen, Schenk, Gerhard, Nash, Kevin, Oddie, Geoff W., Guddat, Luke W., Hume, David A., de Jersey, John, Burke Jr., Terrence R. and Hamilton, Susan E. (2004) Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases. Archives of Biochemistry and Biophysics , 424. pp. 154-162. ISSN 0003-9861

Mitic, Natasa, Saleh, Lana, Schenk, Gerhard, Bollinger, J. Martin Jr. and Solomon, Edward I. (2003) Rapid-Freeze-Quench Magnetic Circular Dichroism of Intermediate X in Ribonucleotide Reductase: New Structural Insight. Journal of the American Chemical Society, 125 (37). pp. 11200-11201. ISSN 0002-7863

Schenk, Gerhard, Neidig, Michael L., Zhou, Jing, Holman, Theodore R. and Solomon, Edward I. (2003) Spectroscopic Characterization of Soybean Lipoxygenase-1 Mutants: the Role of Second Coordination Sphere Residues in the Regulation of Enzyme Activity. Biochemistry, 42 (24). pp. 7294-7302. ISSN 0006-2960

Twitchett, Mark B., Schenk, Gerhard, Aquino, Manuel A. S., Yiu, Douglas T.-Y., Lau, Tai-Chu and Sykes, A. Geoffrey (2002) Reactivity of MII Metal-Substituted Derivatives of Pig Purple Acid Phosphatase (Uteroferrin) with Phosphate. Inorganic Chemistry, 41 (22). pp. 5787-5794. ISSN 0020-1669

Schenk, Gerhard, Boutchards, Clare, Carrington, Lyle E., Noble, Christopher J., Moubaraki, Boujemaa, Murray, Keith S., de Jersey, John, Hanson, Graeme R. and Hamilton, Susan E. (2001) A Purple Acid Phosphatase from Sweet Potato Contains an Antiferromagnetically Coupled Binuclear Fe-Mn Center. Biochemistry, 276 (22). pp. 19084-19088. ISSN 0006-2960

Schenk, Gerhard, Guddat, L.W., Ge, L., Carrington, Lyle E., Hume, D.A., Hamilton, S.E. and de Jersey, J. (2000) Identification of mammalian-like purple acid phosphatases in a wide range of plants. Gene, 250. pp. 117-125. ISSN 0378-1119

Schenk, Gerhard, Korsinczky, Michael L.J., Hume, David A., Hamilton, Susan E. and de Jersey, John (2000) Purple acid phosphatases from bacteria: similarities to mammalian and plant enzymes. Gene, 255. pp. 419-424. ISSN 0378-1119

Oddie, G.W., Schenk, Gerhard, Angel, N.Z., Walsh, N., Guddat, L.W., de Jersey, J., Cassady, A.I., Hamilton, S.E. and Hume, D.A. (2000) Structure, Function, and Regulation of Tartrate-Resistant Acid Phosphatase. Bone, 27 (5). pp. 575-584. ISSN 8756-3282

Schenk, Gerhard, Ge, Yubin, Carrington, Lyle E., Wynne, Ceridwen J., Searle, Iain R., Carroll, Bernard J., Hamilton, Susan E. and de Jersey, John (1999) Binuclear Metal Centers in Plant Purple Acid Phosphatases: Fe-Mn in Sweet Potato and Fe-Zn in Soybean. Archives of Biochemistry and Biophysics , 370 (2). pp. 183-189. ISSN 0003-9861

Schenk, Gerhard, Carrington, Lyle E., Hamilton, Susan E., de Jersey, John and Guddat, Luke W. (1999) Crystallization and preliminary X-ray diffraction data for a purple acid phosphatase from sweet potato. Acta Crystallographica Section D Biological Crystallography, 55 (12). pp. 2051-2052. ISSN 0907-4449

Schenk, Gerhard, Duggleby, Ronald and Nixon, Peter (1998) Heterologous expression of human transketolase. The International Journal of Biochemistry & Cell Biology, 30. pp. 369-378. ISSN 1357-2725

Schenk, Gerhard, Layfield, Roy, Candy, Judith M., Duggleby, Ronald G. and Nixon, Peter F. (1997) Molecular Evolutionary Analysis of the Thiamine-Diphosphate-Dependent Enzyme, Transketolase. Journal of Molecular Evolution , 44. pp. 552-572. ISSN 0022-2844

Schenk, Gerhard, Leeper, Finian J., England, Renee, Nixon, Peter and Duggleby, Ronald (1997) The role of His113 and His114 in pyruvate decarboxylase from Zymomonas mobilis. European Journal of Biochemistry , 248. pp. 63-71. ISSN 0014-2956

Schenk, Gerhard and Duggleby, Ronald (1991) Properties and functions of the thiamin diphosphate dependent enzyme transketolase. The International Journal of Biochemistry & Cell Biology, 30. pp. 1297-1318. ISSN 1357-2725